WebMay 26, 2015 · General procedure for the synthesis of dabigatran analogues (14a–14u) Compound (13a–13u) (2 mmol) was added to a solution of sodium hydroxide (0.24 g, 6.0 mmol) in water/ethanol(30 mL, 2:1 = v/v) and kept stirring at room temperature for 2 h. The mixture was then diluted with 50 mL of water and neutralized with acetic acid. WebDec 1, 2015 · In our previous work, 9 Dabigatran’s central template, benzimidazole, was replaced by 1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine based on the principle of …
Design, synthesis and antithrombotic evaluation of novel …
Webda· big· a· tran də-ˈbig-ə-ˌtran, ˌdab-ə-ˈga-. variants or dabigatran etexilate. -i-ˈtek-sə-ˌlāt. also dabigatran etexilate mesylate. : an anticoagulant drug C34H41N7O5·CH4O3S that … WebDec 1, 2015 · In our previous work, 9 Dabigatran’s central template, benzimidazole, was replaced by 1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine based on the principle of scaffold hopping.And the 4-amidino benzyl group was connected to position 2 of the benzo[4,5]imidazo[1,2-a]pyrazine nucleus, but this kind of linking method may hinder the … ezekiel isiah
The polymorph landscape of Dabigatran etexilate ... - ScienceDirect
WebApr 1, 2010 · Dabigatran etexilate is a competitive reversible non-peptide antagonist of thrombin. Thrombin is a multifunctional enzyme which converts fibrinogen to fibrin, cross-linking fibrin monomers via activation of factor XIII and augmenting further thrombin production via the activation of factors V and VIII. ... Reduced synthesis of functional ... WebDec 1, 2015 · Dabigatran is direct potent thrombin inhibitor. Based on bioisosteric and scaffold hopping principle, two dabigatran mimics (I-1 and II-1) in which the b … Design, synthesis and antithrombotic evaluation of novel dabigatran etexilate analogs, a new series of non-peptides thrombin inhibitors WebIn Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. HMG Co-A reductase inhibitors (statins) The interaction of dabigatran etexilate with atorvastatin has been studied in 22 healthy men and women in an open, randomized, multiple-dose, three-way crossover study [9].They took dabigatran 150 mg bd on days 1–3 and 150 mg/day on day 4, or … ezekiel ito