Phosphatase tensin-type
WebGene Variant Descriptions. PTEN H93Q lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). H93Q demonstrates Pten protein stability similar to wild-type protein ( PMID: 32350270, PMID: 32366478 ), however, results in a partial loss of ability to rescue spheroid formation ( PMID: 32366478 ), fails to suppress Akt ... WebPTEN H93Y lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). H93Y demonstrates loss of phosphatase activity ( PMID: 10866302, PMID: …
Phosphatase tensin-type
Did you know?
WebMay 2, 2024 · Figures. Phosphatidylinositol 3,4,5 Trisphosphate 3 Phosphatase And Dual Specificity Protein Phosphatase PTEN (Mutated In Multiple Advanced Cancers 1 or … WebMar 1, 2001 · Protein tyrosine phosphatase that exhibits also lipid phosphatase activity. Can use phosphatidylinositol substrates such as PtdIns (3,4,5)P 3 as substrate. Pollen-specific …
WebJan 1, 2009 · This enzyme, with a mutation in the active site pocket, retains similar protein phosphatase activity to wild-type PTEN, at least using polyGluTyrP as a substrate, yet has greatly reduced activity, approximately 10% of the wild-type protein's activity, ... Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor and ... Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been identified in most mammals for which complete genome data are available.
WebMay 2, 2024 · PDM [PtdIns (4,5)P 2 -binding motif], Ptase (Phosphatase tensin-type domain), C2 (C2 tensin-type domain), DUF547 (Domain of unknown function), PDZ-BM (PDZ-binding motif), PEST (proline, glutamine, serine, threonine sequence), red triangle indicates the nuclear localization sequence. WebMar 28, 2024 · Among them, Src homology region 2 domain containing phosphatase-1 (SHP1), phosphatase and tensin homolog deleted on chromosome 10 (PTEN), and MAP kinase phosphatase 1 (MKP1) act as negative regulators in OCs. SHP1 is a non-receptor-type PTP, which is a product of Ptpn6.
WebPhosphatase and tensin homolog (PTEN) is a tumor suppressor and component of PI3K-AKT-mTOR signaling. Cowden syndrome is an inherited, autosomal dominant phenotype …
WebSep 15, 2015 · The PI3K signaling cascade in APCs has been recognized as an essential pathway to initiate, maintain, and resolve immune responses. In this study, we demonstrate that a cell type-specific loss of the PI3K antagonist phosphatase and tensin homolog (PTEN) in myeloid cells renders APCs toward a regulatory phenotype. duty roaster july 2018WebMar 21, 2024 · PTEN (Phosphatase And Tensin Homolog) is a Protein Coding gene. Diseases associated with PTEN include Cowden Syndrome 1 and Macrocephaly/Autism … duty registrarWebFeature Type Coordinates Select Strains; C57BL/6J: MGI_C57BL6J_109583: protein coding gene: Chr19:32734897-32803560 (+) 129S1/SvImJ: ... IPR014020 Tensin phosphatase, C2 domain. IPR029023 Tensin-type phosphatase domain. IPR000387 Tyrosine-specific protein phosphatases domain. Molecular Reagents less. All nucleic 41. cDNA 33. duty room meaningWebKey features and details Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply Rabbit monoclonal [EPR9941-2] to PTEN Suitable for: Flow Cyt (Intra), IHC-P, WB Knockout validated Reacts with: Mouse, Rat, Human Related conjugates and formulations Carrier Free HRP You may also be interested in duty roster april 2021WebPTEN (phosphatase and tensin homolog deleted on chromosome 10) was first identified as a tumor suppressor gene localized on chromosome 10q23. PTEN mutations are found at high frequencies in certain tumors, including endometrial carcinomas, gliomas, and breast and prostate cancers. ... Wild-type p53 is polymorphic at residue 72 in exon 4, ... duty risk analysisWebphosphatase and tensin homolog Normal Function The PTEN gene provides instructions for making an enzyme that is found in almost all tissues in the body. The enzyme acts as a tumor suppressor, which means that it helps regulate cell division by keeping cells from … duty room 意味WebPhosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger factor 2 (PREX2) is a novel regulator of the small guanosine triphosphatase Rac, and has been observed to be implicated in human cancer by inhibiting the activity of phosphatase and tensin homolog (PTEN), thus upregulating the activity of the phosphoinositide 3-kinase (PI3K) signaling … csy2f7